姓名：董旻岳

性别：男

籍贯：浙江奉化

所属学科：妇产科学

最后学历：博士

职称：主任医师

研究生导师：博导

研究方向：生殖医学、围产医学

现任职务：院长办公室主任

董旻岳，男，医学博士，博士研究生导师。1985年毕业于浙江医科大学医学系，2000年－2001年在美国伊利诺依大学芝加哥分校（UIC）医学院从事生殖生理学博士后研究。研究领域为生殖医学和围产医学，主要研究方向为妊娠免疫耐受机制、生殖和妊娠相关疾病的免疫学病因与发病机制，近年特别关注滋养细胞功能与妊娠併发症关係以及妊娠併发症对子代影响及机制的研究。主持、承担国家自然科学基金、973项目子课题等课题多项。发表学术论文百余篇，主要论文均发表在SCI刊物，获科技成果奖励6项。

1.Follistatin-like 3对滋养细胞与胚胎的影响以及在妊娠併发症中的作用。2013年国家自然科学基金（课题负责人）

2.子宫内膜细胞脂肪酸结合蛋白4在胚胎着床中的作用与机制研究。2011年国家自然科学基金（课题负责人）

3.辅助生殖诱发胚胎源性疾病的风险评估和机制研究。2011年国家重大科学研究计画（973）项目（学术骨干）

4.Toll样受体7、8介导的炎性反应通路在滋养细胞阻止B型肝炎病毒宫内传播中的作用。2010年浙江省自然科学基金（课题负责人）

1. 提高出生人口质量的生殖技术创建、体系最佳化与临床推广套用：2010年国家科技进步二等奖；

2. 阻断出生缺陷、促进子代健康关键技术体系的创建与推广套用：2010年浙江省科技进步一等奖；

1. He J, Zhang AP, Fang M, Fang R, Ge JM, Jiang Y, Zhang H, HanC, Ye XQ, Yu DQ, Huang HF, Liu Y*, DongMY*. Methylation levels at IGF2 and GNAS DMRs in infants born to preeclampticpregnancies. BMC Genomics, 2013, 14:472.

2. Zhou QY, Li J, Wang HZ, Han C, Tian T, Zhu QY, Huang HF,Dong MY*. Serum preadipocytefactor-1 is increased in fetuses of pregnancy complicated with severepreeclampsia. Clinica Chimica Acta, 2013, 424:212-215.

3. Guo J, Tian T, Lu DH, Xia GY, Wang HZ,Dong MY*.Alterations of maternal serum and placentalfollistatin-like 3 and myostatin in pre-eclampsia. J Obstet Gynecol Res, 2012Jul, 38( 7):988-996.

4. Hu DX, Tian T, Guo J, Wang HZ, Chen DQ,Dong MY*. Decreased maternal and placental concentrations offollistatin-like 3 ingestational diabetes. Clinica Chimica Acta, 2012, 413: 533-536.

5. Yin LJ, Zhang Y, Lv, PP, He WH, Wu YT, Liu AX, Ding GL,Dong MY,QuF, Xu CM, Zhu XM, Huang HF. Insufficient maintenance DNA methylation isassociated with abnormal embryonic development. BMC Med. 2012;10:26.

6. Liu FJ, Guo J, Tian T, Wang HZ, Dong FY, Huang HF,Dong MY*. Placental trophoblastsshifted Th1 ⁄ Th2 balance toward Th2 and inhibited Th17 immunity atfetomaternal interface. APMIS, 2011, 119: 597–604.

7. Wang N, Wang, LY, Le F, Zhan QT, Zheng YM, Ding GL, Chen XJ,Sheng JZ,Dong MY,Huang HF,Jin F. Altered expression of Armet and Mrlp51 inthe oocyte, preimplantation embryo, and brain of mice following oocyte in vitromaturation but postnatal brain development and cognitive function are normal.Reproduction, 2011,142( 3):401-408.

8. Chen D, Xia G, XuP,Dong MY*. Peripartum serumleptin and soluble leptin receptor levels in women with gestational diabetes.Acta Obstet Gynecol Scand. 2010, 89(12): 1595- 1599.

9. Zhang K, He J,Dong MY*. Relationship betweenumbilical artery Doppler waveform analysis and perinatal prognosis in womenwith intrahepatic cholestasis of pregnancy. Int J Gynaecol Obstet. 2010;111(2):187-8.

10.Wang TT, Wu YT,Dong MY,Sheng JZ Leung PC,Huang HF. G546Apolymorphism of growth differentiation factor-9 contributes to the poor outcomeof ovarian stimulation in women with diminished ovarian reserve. FERTILITY ANDSTERILITY. 2010; 94(6): 2490-2492.

11.Liang ZX,Dong MY, Cheng Q, Chen DQ.Gestational diabetes mellitus screening based on the gene chip technique.Diabetes Res Clin Pract, 2010 Aug, 89(2):167-73.

12.Qu F, Wang FF, LuXE,Dong MY, Sheng JZ, Lv PP,Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women withpolycystic ovary syndrome: hyperandrogenism in follicular fluid inhibitsaquaporin-9 ingranulosa cells through the phosphatidylinositol 3-kinase pathway. HUMANREPRODUCTION, JUN 2010, 25(6): 1441-1450

13.Ding GL, Chen XJ,Luo Q,Dong MY, Wang N, Huang HF.Attenuated oocyte fertilization and embryo development associated with alteredgrowth factor/signal transduction induced by endometriotic peritoneal fluid.FERTILITY AND STERILITY, MAY 2010, 93(8): 2538-2544

14.Wei J, Wang HM, Yang XF,Dong MY, Wang ZP. Altered gene profile of placenta from women with intrahepaticcholestasis of pregnancy. Arch Gynecol Obstet, 2010 May, 281( 5): 801-10

15.Lou H, Ding W,Dong MY, Zhu Y, Zhou C, Wang Z,Yang X, Yao Q,Li D, Miao M. The Presence of Hepatitis B Surface Antigen in the Ova ofPregnant Women and Its Relationship with Intra-uterine Infection by Hepatitis BVirus. J Int Med Res, 2010, 38(1): 214-9

16.Tang L, Zhang Y,Pan H, Luo Q, Zhu XM,Dong MY,Leung PCK, Sheng JZ, Huang HF. Involvement of cyclin B1 in progesterone-mediated cell growthinhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell.Reprod Biol Endocrinol, 2009, 7:

17.Shangguan XJ, Liu FJ, Wang HZ, He J,DongMY*.Alterations in serum adipocytefatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia.Clinica Chimica Acta, 2009, 407: 58-61

18.Chen DQ, Wang HZ,Huang HF,Dong MY*. VascularEndothelial Growth Factor Attenuates Nω-Nitro-L-Arginine Methyl Ester-InducedPreeclampsia-Like Manifestations in Rats. Clinical and ExperimentalHypertension. 2008 Oct, 30(7): 606- 615.

19.Chen X, Qian X,Chen H,Dong M*. Serum levelsof nitric oxide metabolites during labour with or without combinedspinal-epidural analgesia. EUROPEAN JOURNAL OF ANAESTHESIOLOGY. 2008 Sep,25 (9): 708-713

20.Feng C, Wang LQ,Dong M, HuangHF. Needfor standardization and confirmation of STS deletions on the Y chromosome – Reply.FERTILITY AND STERILITY. 2008 Aug, 90 (2): 464-464

21.Feng C, Wang LQ,Dong M*, Huang HF. Assisted reproductive technology may increase clinicalmutation detection in male offspring. FERTILITY AND STERILITY, 2008 Jul, 90(1):92-96.

22.Huang H,Dong M*. The effect of trohphoblasts on T lymphocytes and the role of indoamine2,3-dioxigenase. Human Reproduction. 2007 Jul, 22 (Supl 1): 112-112 Meetingabstract O028.

23.Minyue Dong*,Guolian Ding, Jun Zhou, Hanzhi Wang,Yi Zhao, Hefeng Huang. The effect oftrohphoblasts on T lymphocytes: Possible regulatory effector molecules--Aproteomic analysis. Cellular Physiology and Biochemistry, 2008, 21:463-472.

24.Wensheng HU, Zhengping WANG，Hanzhi WANG, Hefeng HUANG andMinyue DONG*. Serum Visfatin Levels in Late Pregnancy and Preeclampsia. Acta ObstetGynecol Scand, 2008 April, 87(4): 413-418.

25.Dongxiao Hu, Zhengping Wang, Wuwen Zhang, Hanzhi Wang, andMinyue Dong*.Alteration of Peripheral CD₄CD₂₅Regulatory T Lymphocytes in Pregnancy and Preeclampsia. Acta Obstet GynecolScand, 2008, 87(2): 190-194.

26.Qingxia Meng, Huijuan Gao, Chengming Xu,MinyueDong, Xia Sheng, Jiangzhong Sheng,Hefeng Huang. Reduced Expression and Function of Aquaporin-3 in Mouse Metaphase II Oocytes Induced byControlled Ovarian Hyperstimulation Were Associated with Subsequent Lowfertility Rate. Cell Physiol and Biochem, 2008; 21: 123-128.