李明雪

李是输果就明雪，女，1971年3月生，副教授，目前主要从事金属配合物的设计和生物活性的基础研究。重点是设计一些具有生物活性的配体及其金属配合来自物，评价所合成的化合360百科物的抗肿瘤活性及肿须必转甲节队瘤治疗选择性的影响，初步分析配体的构效关系，分析金属的引入对配体生物活性的影响，进一步筛选出抗癌谱广，生兵什个兴部无曾物活性高、毒性间位再要层是相则小的金属配合物，为新药研究开发奠定基础。

• 中文名称 李明雪
• 出生日期 1971年3月
• 毕业院校 河南大学
• 职称 副教授
• 性别 女

个人履历

　　19培美问害学委速香年值91.9-1995.7河南大学化学系学士;

　　1995.衡甚制怀也商7-1999.9河南省开封制药厂助理工程师;

　　1999.9-2002.7河南大学无机化学硕士

　　2002.9-2005.6南京大学无机化学博士

现妈价守　　2002.7至今，河南大学讲师、副教授、硕士生导师、河南省教育厅学术技术带头人

主持项目

　　1. 2006年河南省科技厅计划项目:茂铁基金属配合物的来自合成和性质研究(061101360百科1900);2006.1-2008.12;资助金额2万元;即将结项

　　2. 2007年度河南省教育厅自然科学研究项目:氨基硫脲金属配合物的合成和生物活性研究(2007150012); 2007.1-可地主2009.1;资助金额1万元;即将结项

获奖情况

　　1. 2006年获省第九届自附律手施阶银始精装然科学优秀论文奖

　　1评电两集印的) Octanuclear metallocyclic Ni4Fc4 compound: Synthesis, crystal structure, and electrochemical sensing for Mg2+

　　2) Organosilyl derivatives of trivacant tungstophosphate of general formula alpha-A-[PW9O34(RSiO)3(RSi)]3 Synthesis and structure determination by X-ray crystallography

　　2.2006年获河南省教育厅科技论文奖

　　1) Octanuclear metallocyclic Ni4Fc4 compound: Synthesis, crystal stru儿非跟cture, and electrochemical sensi来自ng for Mg2+

　　2) Heterodim空孙烧晚续etallic Compounds Assembled from Ferroce360百科ne-containing Bisthiosemicarbazon氢温多械操皮土e Clips》

　　3. 2008年度河南省教育厅科技论文奖

　　1) Hete永rodimetal非帝末论求呼川雷lic Compounds Assembled from Ferrocene-containing Bisthiosemicarbazone Clips

　　2) Sy点史烈验nthesis and crystal structure of a Mn(II) complex with thiosemicarbazone derivativeof pyridine-3-carbaldehyde showing unusual coordination modes of tridentate thiosemicarbazone

　　3) Chiral aggregation and spontaneous resolution 常齐受含of thiosemicarbazone metal complexes

　　4) Hydrothermal synthesis and crystal structure of a 1D fourfold-chain polyoxometalate-based com紧粉顺确余复成封plex[Cu(4,4ˊ-济训留增例增杀别状bipy)]2[SiW12O4身每般工屋青开模用兰顺0{Cu(4,4ˊ -bipy)}4]∙(OH)2·H2O

　　4. 2008年荣获河南省科学技术进步奖叁等奖1项

代表性论文

　　1. Ming-xue Li, Pin沉危矛因失g Cai, Chun-yin机何磁越意g Duan, Feng Lu, 扩觉利胶万Jin Xie, Qi洲排离道助肉思包ng-jin Men剧艺g Octanuclear Metall销守形假肥缩型云ocyclic Ni4Fc4 Compound: Synthesis, Crystal Structure, and Electrochemical Sensing for Mg2+. Inorg. Chem. 2004, 43, 5174– 5176.

　　2. Ming-xue Li, Yan Bai, Bing-guang Zhang, Chun-ying Duan, Jian Xu, Qing-jin Meng，Heterometallic Compounds Assembled from Ferrocene-Containing Bisthiosemicarbazone Clips. Inorg. Chem. 2005，44，5459– 5466.

　　3. Ming-xue Li, Qiao-zhen Sun, Chun-ying Duan etal. Chiral aggregation and spontaneous resolution of thiosemicarbazone metal complexes. J. Chem. Soc., Dalton Trans. 2006, 2572–2578.

　　4. Ming-xue Li, Chun-ling Chen, Chun-sheng Ling, Jing Zhou, Bian-sheng Ji, Yan-juan Wu, Jing-yang Niu. Bioorganic & Medicinal Chemistry Letters, 2009，19，2704-2706.

　　5. Ming-xue Li, Jing Zhou , Hong Zhao , Chun-Ling Chen, Jing-ping Wang. Iron(III) Complex of 2-Acetylpyrazine Thiosemicarbazone: Synthesis, Spectral Characterization, Structural Studies and Antitumoral Activity. Journal of Coordination Chemistry,2009, , 6 2( 9) ， 1423 –1429.

　　6. Ping Cai, Ming-xue Li, Chun-ying Duan, Feng Lu, Qing-jin Meng . Synthesis and Properties of the Geometrically Controlled Mixed-Valence Tetrahedral RuII2RuIII 2L6 Cluster. Eur.J. Inorg. Chem. 2005 ，2581– 2585.

　　7. Ping Cai, Ming-xue Li, Chun-ying Duan, Feng Lu, Dong Guo and Qing-Jin Meng Syntheses, crystal structure and electrochemical properties of dinuclear ruthenium complexes containing saturated and unsaturated spacers New. J. Chem..2005，29，1011– 1016.

　　8. Ming-xue Li, Juan Du, Jing-Ping Wang, Jing-Yang Niu Hydrothermal synthesis and crystal structure of a 1D fourfold-chain polyoxometalate-based complex [Cu(4,4′-bipy)]2[SiW12O40{Cu(4,4′-bipy)}4] · (OH)2 · H2O. Inorg.Chem.Commun. 2007,10(12) 1391– 13931.

　　9. Ming-xue Li, Gui-ling Guo， Jing-yang Niu. A new organic-inorganic hybrid material constructed from Keggin polyanion and transition metal complexes: [Co(2,2'-bipy)3]1.5[SiWVWVI 11O40Co(2,2'-bipy)2(H2O)] · 0.5H2O J. Coord. Chem., 2008 , 61( 18)， 2896 – 2904

　　10. Ming-xue Li, Gui-ling Guo， Jing-yang Niu, A new hybrid material constructed from octamolybdate anion and neutral dinuclear copper units. J. Coord. Chem. 2008 , 61( 23)， 3860 – 3868.

　　11. Ming-xue Li, Jing Zhou , Hong Zhao , Chun-ling Chen, Jing-ping Wang. Iron(III) Complex of 2-Acetylpyrazine Thiosemicarbazone: Synthesis, Spectral Characterization, Structural Studies and Antitumoral Activity. J. Coord. Chem.,2009, , 6 2( 9) ， 1423 –1429.

　　12. Li Ming-Xue, Zhou Jing, Wang Jing-Ping，Wang, Zi-Liang. Synthesis and Crystal Structure of Mn(Ⅱ)Complex with Thiosemicarbazone Derivative of Pyridine-3-Carbaldehyde Showing Unusual Coordination Mode of Tridentate Thiosemicarbazone，Chinese J. Struct. Chem. 2006, 25, 1275– 1279.

　　13. Ming-xue Li, Jing Zhou, Jing-ping Wang, Zi-liang Wang. Antitumor Metallothiosemicarbazonate:Synthesis, Crystal Structure, Spectra and Antitumor Studies of Co(III) Complex withThiosemicarbazone Derivative of 2-Benzoylpyridine. Chinese J. Struct. Chem. 2008, 27(3), 281– 286.

　　14. Ming-xue Li, Jing Zhou, Zi Liang Wang, Jing-ping Wang. Synthesis, Crystal Structure and Antitumor Study of a Cobalt(II)Complex of the 2-Acetylpyrazine Thiosemicarbazone,Z. Naturforsch. 2008, 63b, 1 – 5.

　　15. Ming-xue Li, Jing Zhou, Chun-ling Chen, Jing- ping Wang. Synthesis, Crystal Structure and Antitumor Study of a Zinc Complex of the 2-Benzoylpyridine Thiosemicarbazone Ligand Z. Naturforsch. 2008, 63b, 280 – 284.

　　16. Ming-xue Li, Hong-yu Niu, Wei Wang, Jing-pingWang. A Keggin-type Arsenotungstate Anion-supported Transition Metal Complex: Hydrothermal Synthesis and Characterization of [Fe(2,2_-bipy)3]1.5[AsWVI10WV 2O40Fe(2,2_-bipy)2(H2O)] · 0.25H2O Z. Naturforsch. 2008, 63b, 183 – 186.

　　17. Ming-xue Li, Kai-hau Wang， Jing-yang Niu. Hydrothermal Synthesis and Crystal Structure of [Cu(en)2(H2O)]2{PW11.5Cu0.5O40[Cu(en)2]}·2H2O.Chinese J. Struct. Chem. 2008, 27(3), 340– 344.

　　18. 李明雪 ， 周静，王子梁，王敬平. 一维单链4-吡啶甲醛缩氨基硫脲合锌(Ⅱ)配位聚合物[Zn(HL)(CH3COO)2·H2O]n的合成、晶体结构及配体的新颖配位模式 应用化学，2008，25(1), 48– 52。