龙加福

龙加福，现任来自南开大学生命科学学院教授，  博士生将成州怎笑导师，  校特聘教授价米势，药物化学生物学国家重点实验室固定PI 。1999年毕业于南开大学360百科生命科学学院生物化学及分子生物学系， 获得学士合承较材频里今季洲学位， 同年9月善卷式言车巴进入香港科技大学生物化学系学习，师从张明杰院士，2004年8月获得香港科技大学生物化学博士学位。2004年9月至2007年2月于香港科技大学生物化学系从事博士后研究。

• 中文名称 龙加福
• 国籍 中国
• 民族 汉
• 毕业院校 南开大学、香港科技大学
• 职业 教师

经历

　　龙加福教授自2007年01月独立主持实验室以来，运用多学科交叉的手段和方法系统地研究蛋白质或复合乡物的结构与功能，现主要研究方向是基因表达调控与疾病，相对系统的研究了组蛋白修饰复合物的装配机理及染色质变构的调节机制。研究成果阐明了参与组蛋来自白修饰的Elongator复合物装配的分子机制和PAF1复合物特异识别组蛋白底物的作用机理。揭示了360百科染色质变构因子SATB1多聚化的分子机制及其多聚化参与调节染色质高级结构的可能作用机理。从生物化学及结构生物学的角度推动了多蛋白功能复合物参与基因表达调控的表观遗传学机制，为科学发展做出了一定贡献。美善未主持973计划子课题、国家自然科学基金、天津市自然科学基金重点项目等。科研论文主要发表在Nat Struct Mol Biol、PNAS、Cell Res、Angew Chem Int Ed、Nucleic Acids Res、Structure和JBC等国际知名杂志。

方向

　　我们运用生物化学、结构生物学(包括液体核磁共振和X-射线晶体学)、分子及细胞生物学的手段和方法系统地研究蛋白质或复合物的结构与功能。现实验室主要进行以下项目的研究:表观遗传调控蛋白的结构与功能;参与细胞极性调控的蛋白复合物的分子机理;与人类重大疾病相关蛋白的作用机理。作为通讯作者或第一作者在国际著名杂志Angewandte Chemie Int.Ed., Nature St目细临卫介须观买利找吧ruc.Mol.Biol., PNAS, Nucleic Acids Res., FASEB J., JBC, JMB等发表论文和其它论文共近二十节客篇。

　　基因表达调控与含误技月疾病

　　1. 组蛋白修食界钱来克高六站省饰复合物的装配机理

　　2. 染色质变构的调节机制

　　3. 与人类重大疾病相关蛋白的作用机理

荣誉称号

　　1. 2007年 教育部来自新世纪优秀人才支持计划

　　2. 2014年 天津市自然科学一等奖(第五完成人)"超分子水凝胶的制备及生物医疗应用"

　　3. 2肥六联肉015年 第十三届天津青年科技奖

　　4. 2016年 入选"南开大学2015处年度十大科技进展"项目

　　5. 2016年 第七届赛诺菲-Cell Research优秀论文奖

研究成果

　　1."Supramodular structure and synergistic target binding of the N-te久胞各超到美矿她约绿当rminal tandem PD360百科Z domains of PSD-95", Long, J., Tochio, H., Wang, P., Fan J.-S,. Sala, C., nietha仅止常际婷脱mmer, M., Sheng, M. and Zhang, M., J. Mol. Biol., 327(1): 203-214 (2003).

　　2."The t眼款集形精段终剂肉etrameric L27 domain complex as an or费老财ganization platform for 向格联货诉程养supramolecular assemblies", Feng, W.,Long, J.(equal contribution), Fan, J,-S., Suetake, T., Zhang, M.员丰诗头雷先立伯导灯零, Nat. Str独稳层里师护高高uct. Mol. Biol., 11(5):475-480 (2004).

　　3. "A unified assembly mode revealed by the structur须格当世织功es of tetrameri何通c L27 domain compl对得须入未鸡exes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins", Feng, W., Long, J.(equal c报ontribution), Zhang, M.,Proc. Natl. Acad. Sci. USA, 102(19): 6861-6866 (2005).

　　4."Autoinhibition of X11/Mint Scaffold Proteins Revealed by the Cl毫分消称风似达械osed Conformatio河束n of the PDZ Tandem", Long, J., 婷拿积获厂古特向们Feng, W., Wang, R., Chan, L.-N., Fanny, Ip. Xia, J., Nancy, Ip. Zhang, M., Nat. Struct. Mo促落我满l. Biol., 12(8): 722-728 (2005).

　　5."Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1", Long, 友需面错根晚福J., Wei, Z., Feng, W., Yu, C., Zhao, Y. –X., Zhang, M., J. Mol. Biol., 375(5):1457-1468 (2008).

　　6."Structural basis of b-catenin Recognition by Tax-interaction Protein-1", Zhang, J., Yan, X., Shi, C., Yang, X., Guo, Y., Tian, C., Long, J.*, Shen, Y.*, J. Mol. Biol., 384(1): 255-263 (2008). (*: Co-corresponding author).

　　7. "Molecular Mechanism of Inward Rectifier Potassium Channel 2.3 Regulation by Tax-interacting Protein-1", Yan, X., Zhou, H., Zhang, J., Shi, C., Xie, X., Wu, Y., Tian, C., Shen, Y.*, Long, J.*, J. Mol. Biol., 392(4): 967-976 (2009).

　　8. "Structural basis for tandem L27 domain-mediated polymerization", Yang, X., Xie, X., Chen, L., Zhou, H., Wang, Z., Zhao, W., Tian, R., Zhang, R., Tian, C., Long. J.*, Shen, Y.*, FASEB J., 24(12): 4806-4815 (2010).

　　9. "The structural basis for the oligomerization of the N-terminal domain of SATB1", Wang, Z., Yang, X., Chu, X., Zhang, J., Zhou, H., Shen, Y.*, Long, J.*, Nucleic Acids Res., 40(9): 4193-4202 (2012).

　　10. "Structure of an L27 domain heterotrimer from the cell polarity complex Patj/Pals1/Mals2 reveals a mutually independent L27 domain assembly mode", Zhang, J., Yang, X., Wang, Z., Zhou, H., Xie, X., Shen, Y.*, Long, J.*, J. Biol. Chem., 287(14): 11132-11140 (2012).

　　11. "Rational design of a tetrameric Protein to enhance interactions between self-assembled fibers confers molecular hydrogels", Zhang, X., Chu, X., Wang, L., Wang, H., Liang, G., Zhang, J., Long, J.*, Yang, Z.*, Angew. Chem. Int. Ed., 51(18): 4388-4392 (2012).

　　12. "Crystal structure of Elongator subcomplex Elp4-6", Lin, Z., Zhao, W., Diao, W., Xie, X., Wang, Z., Zhang, J., Shen, Y.*, Long, J.*, J. Biol. Chem.287(25): 21501-21508 (2012).

　　13. "Open-closed mechanism of Mint2 regulates APP metabolism", Xie, X., Yan, X., Wang, Z., Zhou, H., Diao, W., Zhou, W., Long, J.*, Shen, Y.*, J. Mol. Cell Biol.5(1): 48-56 (2013).

　　14. "Multifunctional biohybrid hydrogels for cell culture and cotrolled drug release", Wang, H., Han, A., Cai, Y., Xie, Y., Zhou, H.*, Long, J.*, Yang, Z.*, Chem. Commun., 49(67): 7448-7450 (2013).

　　15. "Growth stimulation of bacterium Delftia by a peptide hydrogel", Du, X., Wu, Z.,Long, J.*, Wang, L.*, RSC Adv., 3(40): 18259-18262 (2013).

　　16. "Structural insights into Paf1 complex assembly and histone binding", Chu, X., Qin, X., Xu, H., Li, L., Wang, Z., Li, F., Xie, X., Zhou, H., Shen Y.*, Long, J.*, Nucleic Acids Res., 41(22): 10619-10629 (2013).

　　17. "Rational design of multifunctional hetero-hexameric proteins for hydrogel formation and controlled delivery of bioactive molecules", Zhang, X., Zhou, H., Xie, Y., Ren, C., Ding, D.*, Long, J.*, Yang, Z.*, Adv. Healthc. Mater., 3(11): 1804-1811 (2014).

　　18. "Crystal structure of the Ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism", Wang, Z., Yang, X., Guo, S., Yang, Y., Su, X-C., Shen, Y.*, Long, J.*, J. Biol. Chem., 289(40): 27376-27385 (2014).

　　19. "A genetically modified protein-based hydrogel for 3D culture of AD293 cells", Du, X., Wang, J., Diao, W., Wang, L., Long, J.*, Zhou, H.*, PLoS One, 9(9): e107949 (2014).

　　20. "The Elp2 subunit is essential for Elongator assembly and functional regulation", Dong, C., Lin, Z., Diao, W., Li, D., Chu, X., Wang, Z., Zhou, H., Xie, Z., Shen, Y.*, Long, J.*, Structure, 23(6): 1078-1086(2015).

　　21. "Angiomotin binding-induced activation of Merlin/NF2 in the hippo signaling pathway", Li, Y., Zhou, H., Li, F., Chan, S., Lin, Z., Wei, Z., Yang, Z., Guo, F., Lim, C., Xing, W., Shen, Y., Hong, W., Long, J.*, Zhang, M.*, Cell Res., 25(7): 801-817 (2015).

　　22. "Dimerization of elongator protein 1 is essential for Elongator complex assembly", Xu, H., Lin, Z., Li, F., Diao, W., Dong, C., Zhou, H., Xie, X., Wang, Z., Shen, Y.*, Long, J.*, Proc. Natl. Acad. Sci. USA, 112(34): 10697-10702 (2015).

　　23. "Self-assembly molecular chaperone to concurrently inhibit the production and aggregation of amyloid b peptide associated with Alzheimer's disease", Hang, F., Qu A., Yang H., Zhu L., Zhou, H., Liu J., Long J.*, and Shi L.*, Acs Macro lett., 7: 983-989 (2018).

　　24. "Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation", Xie Y., Zheng M., Chu X., Chen Y., Xu H., Wang J., Zhou, H.*, Long J.*, Nat. Commun., 9(1): 3795 (2018).

　　25. " Treatment with Humanized Selective CD19CAR-T Cells Shows Efficacy in Highly Treated B-ALL Patients Who Have Relapsed after Receiving Murine-Based CD19CAR-T Therapies", Zhao Y., Liu Z., Wang X., Wu H., Zhang J., Yang J., Zhang F., Liu L.,Long J.*, Lu P.*, Chen Z.*, Clin Cancer Res., 25(18): 5595-5607 (2019).