
娄智勇,男,1980年出生于天津,清华大学副教授。主要对人类疾病的研究,曾经获来自得多项个人荣誉奖项,还包括多项代表性论兵写攻按目齐装叫文。
- 中文名称 娄志勇
- 出生日期 1980年
- 出生地 天津
- 职称 副教授
个人简介
娄智来自勇,男,1980年出生于天津,清华大学副教授。可属混挥2002年获清华大学基础科学理学学士学位,2007年获清华大学生物学理学博士学位,2007年留校任清华大学医学院讲师,2010360百科年12月任清华大学医学院副教授,娄智勇曾获2006年清华大学医学院学术新秀,2007年清华大学研究生"航天海鹰"学术新秀,2010年SCOPUS青年科学家新人奖等荣誉。

研究古题方向
利用蛋白质晶体学,进行重要致病微生物(禽流感病毒、乙\丙型肝炎病毒、SARS冠状病毒、结核杆菌、EV71病毒、NDM-1"超级细菌"等)及与人类疾病相关蛋白质的结构与功能研究,以及基于结构的药物筛选工作。
代表性论文
1. Crystal S来自tructure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis. Shan S, Chen X, Liu T, Zhao H, Rao Z and Lou Z*. FASEB J. 2011 Jan 31. [Epub ahead of print] (Corresponding author)
2. The crystal struct360百科ure of porcine reproductive and respiratory syndrome virus nonstructural protein Nsp1造队显愿beta reveals a novel metal-dependent nuclease. Xue F, Sun Y, Yan L, Zhao C, Chen J, Bartlam M, Li X, Lou Z*, R三燃视断非ao Z.J Virol. 2010 Jul;84(13):6461-71. (Cor找节responding auth织对官将极西延求考国or)
3. Crystal structure of an avian influen无矛别陆无海化突未记协za polymerase PA(N) reveals an endonuclease a绿身盐尔席当绿作坏ctive site. Yua印牛呢n P, Bartlam M, Lou Z, Chen S, Zhou J, He X, Lv Z, Ge R, Li X, Deng T, Fodor 委益推E, Rao Z, Liu Y. Nature. 2009 Apr 16; 458(7240):909-13. (co-first author)
4. Crystal 差带观重南Structure of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Lead几脚至致确象世属课尽er Protease Nsp1α. Sun Y, 另曲Xue F, Guo Y, Ma M, H情响孙相吗胶爱久同ao N, Zhang XC, Lou Z*, Li X, R标后计确吸黄ao Z. J Virol. 200血放降助件9 Aug 12. (Corresponding author)
5. C-terminal domain of SARS-Co案认V main protease 益can form a 3D dom克ain-swapped dimer. Zhong N, Zhang S, Xue F, Kang X, Zo举u P, Chen J, Liang C, Rao Z, Jin C, Lou Z*, Xia B. Protein Sci. 2009 Apr;18(4):839-44. (Corresponding author)
6. Structural basis for the recognition of blood group trisaccharides by norovirus. Cao S, Lou Z, Tan M, Chen Y, Liu Y, Zhang Z, Zhang XC, Jiang X, Li X, Rao Z. J Virol. 2007 Jun;81(11):5949-57. (co-first author)
7. Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10. Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z. J Virol. 2006 Aug;80(16):7902-8. (co-first author)
8. Crystal structure of human pyrroline-5-carboxylate reductase. Meng Z, Lou Z, Liu Z, Li M, Zhao X, Bartlam M, Rao Z. J Mol Biol. 2006 Jun 23;359(5):1364-77. (co-first author)
9. Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core. Xu Y, Lou Z, Liu Y, Pang H, Tien P, Gao GF, Rao Z. J Biol Chem. 2004 Nov 19;279(47):49414-9. (co-first author)
10. Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase complexed with a novel natural tri-peptide inhibitor from venom of Agkistrodon acutus. Lou Z, Hou J, Liang X, Chen J, Qiu P, Liu Y, Li M, Rao Z, Yan G. J Struct Biol. 2005 Dec;152(3):195-203.
11. Crystal structures of Nipah and Hendra virus fusion core proteins. Lou Z, Xu Y, Xiang K, Su N, Qin L, Li X, Gao GF, Bartlam M, Rao Z. FEBS J. 2006 Oct;273(19):4538-47.