严汉池

男，博士，清华大学副研究员，1993-1997年武汉大学生命科学学院，生物化学学士，1997-2000年湖北省医药工业来自研究所，药理学研究实习员;2000-2006年中国科学院生物物理研究所，生物物理学博士;2006-2010年普林斯顿大学，分子生物学系博士后;2010-至今清华大学医学院副研究员。

• 中文名称 严汉池
• 职业 清华大学副研究员
• 毕业院校 武汉大学
• 研究方向 膜蛋白结构生物学

研究来自方向

　　膜蛋白结构生物学，运用以X-射线晶体学为主的结构生物学手段结合生物化学、生物物理学等其它方法研究与生命活动或疾病发生相关的重要膜蛋白的结构与功能; 药物研发相关的药理学及毒理学科客块研究。

发表论文

　　1. Feng L1, Yan H1, Wu Z1, Yan N, Wan道g Z, Jeffrey PD, Shi Y. Structure of a Site-2 Protease Family Intramembrane Metalloprotease Science. 2007; 318:1608-12板再风及审素. (1 equal contributions)

　　2. Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S& Shi Y. Structural analysis of a rhom360百科boid family intramembrane pro终你矛十精非探tease reveals a gating mechanism for substrate entry倒者延儿. Nat Struct Mol Biol. 2006; 13:1084-望制云知施混通91.

　　3. Yan H1, Zhang P1, Wang C, Liu Z, and Chang W. Two lut想八结待练刘师他远沉ein molecules in LHCII have different confor件书杨之空mations and functions: Insights into the molecular me算备神孩断进呼目chanism o交乎视f thermal dissipation in pla律nts. Biochem Biophys Res Commun. 2007; 355:457-463. (1 equal contributions)

　　4. Liu Z, Yan H, Wang K, Kuang T, Zhang J, Gui L, An X & Chang W. Crystal structure of spinach major light-harvesting complex at 2.72 Å resolution. Nature. 2004; 428:287-292. (Highlighted Cover-Story Article)

　　5. Pan J, Li J, Qiu Y, Ling S, Ya妈丝必夫立气n H. Experimental Study on Pharmacodynamical of Zhitongan Xunxiji. L府烟书属ishizhen Medicine And Ma岩掉候模teria Medica Research. 200找示方移规氧独较规6; 17(7):1163-1165.

　　6. Pan J, Li J, Qiu Y, Yan 由判房H, Ling S. The safety 背高只丰未称异evaluation o刑模乐义测名元么待f erythromycin stinoprate. Chinese Journal of New Drugs. 2006; 15 (4):276-280.

　　7. Pan J, Li J, Qiu Y, Yan H, Ling S. A Toxicological Study of Doxepin Hydrochloride Cream in Animals. Herald of Medicine. 2006; 25(2):99-101.

　　8. Pan J, Li J, Qiu Y, Yan H, Ling S. Acute Toxicity Study of Erythromycin Propionate-N-acetylcysteinate. Journal of Mathematical Medicine. 2006; 19(2):176-177.

　　9. Pan J, Li J, Qiu Y, Yan H, Ling S. Study on the Teratogenicity of Erythromycin Propionate-N-Acetylcysteinate in Rats. Carcinogenesis, Teratogenesis and Mutagenesis. 2006; 18(1): 32-34.

　　10. Pan J, Li J, Qiu Y, Yan H, Ling S. The anti-itching and anti-hypersensitivity effects of Doxepin hydrochloride cream. Chinese Pharmacological Bulletin. 2005; 21(12):1505-1508.

　　11. Pan J, Li J, Qiu Y, Yan H, Ling S. Long-term toxicity of Doxepin Hydrochloride Cream in rabbits. Practical Journal of Medicine & Pharmacy. 2005; 22(10):904-906.

　　12. Pan J, Li J, Qiu Y, Yan H, Ling S. Long-term toxicity of erythromycin propionate-N-acetylcysteinate in rats. Chinese Journal of New Drugs. 2005; 14 (9):1133-1135.

　　13. Qiu Y, Cao J, Wang D, Yan H, Ling S, Zhou S, Xu Q. Tissue Residues of Sarafloxacin Hydrochloride in Broiler Chickens. Chinese Journal of Veterinary Science. 2005; 21:515-518.

　　14. Qiu Y, Wang D, Zhou S, Cao J, Cai Q, Li T, Wang X, Zhou Z, Yan H, Ling S. Comparative Pharmacokinetics of Metabolite of Albendazole Oxide and Albendazole in Sheep Body. Journal of Huazhong Agricultural University. 2000; 19:461-464.

　　15.Cao J, Qiu Y, Wang D, Zhou L, Zhou S, Xu Q, Yan H, Jiang M. Pharmacokinetics of sarafloxacin hydrochloride in chickens after intravenous and oral administration. Journal of Huazhong Agricultural University. 1999; 18:248-251.