高艳锋

高艳锋，  博士，   郑州大学生命科来自学学院。2009年晋升副教授，2013年6月破格聘为博士生导师，2014年破格聘为教授。河南省杰出青年基金获得者，河南省优秀中青年骨干教师，郑州大学青年骨干教师。河易音格困本饭土胜助南省生物化学与分子生物学会秘书长，教育部学位论文评审专家。美国免疫学会(AA360百科I)会员，美国癌症学会(AACR)会员，中国免疫学会高级会员，Chinese Journal of Biolog卷知四y杂志编委。Canc真让照er Letters, Bioorganic & Medicinal Chemistry Letters，Peptides，Protein & Peptide Letters和Journal of Food Biochemistry等SC带触危温I杂志的审稿专家。

• 中文名称 高艳锋
• 毕业院校 郑州大学
• 主要成就 河南省自然科学优秀论文一等奖2项
• 职称 教授

课题

　　[1]国家自然科学基金(811728来自93)(主持):PD-1/PD英治机只守古食-L1拮抗肽的筛选及其在肿瘤免疫治疗中的应用研究，起止年月:2012年~2015360百科年

　　[2]国家自然科学基金(30901362)(主持):乳腺癌PIWIL2、PLAC1抗原HLA-A2限制性CTL表位鉴定以及综合改造策略更还型践类子研究，起止年月:2010年~2012年

　　[3]"十二距五"科技部"重大新药创制"重大专项(2012ZX09103301-0卫居女策参论23)(第2参与人):新型抗肿瘤多肽药物AS16的研制，起止年月:2012年~2015年

　　[4]河南省青年骨干教师资助计划(2010GGJS-016)(主持):靶向细胞周期的新型抗肿瘤多肽的设计与活性研究，起止年月:2010年去喜率其别扬殖附式过坐~2012年

　　[5]河南省基础与前沿技术项目(102300410077)(主持):基于MazEF复合物的新型抗菌肽的设计、合成与构效关系研究，起止年月:2010年~2012年

　　[6]河南省次定罗跳混架额医学科技攻关项目(2010举识03008)(主持):基于CT抗原的乳腺癌HLA挥单-A2限制性抗原肽表位的筛选，起止年月:2010年~2012年

　　除坏好去套乐[7]河南省科技攻关项目(072102330038)(主持):新型肿瘤抗原肽和广谱疫鱼苗的研究，起止年月:2007年~2009年

　　[8]河南省医学她应蛋科技攻关项目(2007030紧另切星13)(主持):基于Cyclin/CDK复合物结构的抗肿瘤多肽的研究，起止年月:2007年~2009年

　　[9]教育部大学生创新实验项目(101045910)(指导教师):群体感应信号分子EDF在大肠杆菌中的作用靶点和信号转导途径的研推材乙重谓片走另究. 起止年月:2010年煤滑会衡触久及按科更~2011年

　　[10]郑州大学引进人才启动基金项目(主持)，起止年月:2006年~2008年

　　[11]河南省重点科技攻关言建及容陈胶全阻仅团项目(112102310068)(第2参与人):结核耐药相关抗原CTL表位的筛选与疫苗研制. 起止年月:2011年~2013年

　　[12]河南省杰出人才计划项目(084200510014)(第2参与人):结核病抗原肽表位的筛选和多价疫苗的研制. 起止年月:2008年~2010年

个人成就

主要论文

　　[1] Shi RR, Liu J, Zou Z, Qi YM, Zhai MX, Zhai WJ,Gao YF*. The immuno排虽着图影弦硫走genicity of a novel cytotoxic T lymphocyte epitope from tumor antigen PL2L60 could be en材赵村假庆草情沿洲脱hanced by 4-chlorophenylala律镇士修久获思责愿院nine substitution at position 1. Cancer Immunol Immunother. 2013, 62(11):1723-32.

　　[2] Haili Wang, Xi Chen, Yanping Chen, Lei Sun, Guodong Li, Mingxia Zhai, Wenjie Zhai, Qiaozhen Kang, Yanfeng Gao*, Yuanming Qi*. Antitumor activity of novel chimeric peptides derived from cyclinD/CDK4 and the protein transduction domain 4. Amino Acids, 2013, 44(2):499-510.

　　[3] Ji Z, Shi X, Liu X, Shi Y, Zhou Q, Liu X, Li L, Ji X, Gao Y, Qi Y, Kang Q. The membrane-cytoskeletal protein 4.1N is involved in the process of cell adhesion, migration and invasion of breast cancer cells. Exp Ther Med. 2012, 4(4):736-740.

　　[4] Yahong Wu, Yanfeng Gao*, Yujie He, Ranran Shi, Mingxia Zhai, Zongyin Wu, Meng Sun, Wenjie Zhai, Xi Chen, Yuanming Qi*. A novel cytotoxic T lymphocyte epitope analogue with enhanced activity derived from cyclooxygenase-2. Scand J Immunol. 2012, 76(3):278-85.

　　[5] Chao Dai, Zhaoqing Xu*, Fei Huang, Zhengkun Yu*, Yan-Feng Gao*. Lewis Acid-Catalyzed, Copper(II)-Mediated Synthesis of Heteroaryl Thioethers under Base Free Conditions. Journal of Organic Chemistry. 2012, 77(9):4414-9.

　　[6] Fei Chen, Mingxia Zhai, Yuhuang Zhu, Yuanming Qi, Wenjie Zhai, Yanfeng Gao*. In vitro and in vivo identification of a novel cytotoxic T lymphocyte epitope from Rv3425 of Mycobacterium tuberculosis. Microbiology and Immunology. 2012, 56(8):548-53.

　　[7] Zongyin Wu, Yanfeng Gao*, Yahong Wu, Wei Liu, Meng Sun, Mingxia Zhai, Yuanming Qi, Yong Ye. Identification of a novel CD8+ T cell epitope derived from cancer-testis antigen MAGE-4 in oesophageal carcinoma. Scand J Immunol. 2011, 74:561-567.

　　[8] Wei Liu, Mingxia Zhai, Zongyin Wu, Yuanming Qi, Yahong Wu, Chao Dai, Meng Sun, Lu Li, Yanfeng Gao* Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancer. Amino Acids. 2012, 42(6):2257-65.

　　[9] Yu-huang Zhu, Yan-feng Gao*, Fei Chen, Wei Liu, Ming-xia Zhai, Wen-jie Zhai, Yuan-ming Qi*, Yong Ye. Identification of novel T cell epitopes from efflux pumps of Mycobacterium tuberculosis. Immunology Letters. 2011, 140(1-2):68-73.

　　[10] Jun-wei Zhao, Zhan-qiang Sun, Hong-guo Yang, Chong-zhen Zhang and Xiao-li Yu, Zi-lu Wen, Yan-feng Gao, Xiao-kui Guo, Yuan-ming Qi, Shu-lin Zhang. Cloning, expression and immunological evaluation of a short fragment from Rv3391 of Mycobacterium tuberculosis. Annals of Microbiology, 2011, 61(2):345-353.

　　[11] Hong Lv, Yan-feng Gao*, Ya-hong Wu, Ming-xia Zhai, Lu Li, Yu-huang Zhu, Wei Liu, Zong-yin Wu, Fei Chen, Yuan-ming Qi. Identification of a novel cytotoxic T lymphocyte epitope from CFP21, a secreted protein of Mycobacterium tuberculosis. Immunology Letters. 2010, 133(2):94-8.

　　[12] Yanfeng Gao*, Kun Chen, Bin Zhang, Xiang Li, Lu Chen, Yuanjun Li, Xiangjiao Jia, Yongxing Lei, Zhongyi Yan, Liangliang Kong, Nan Wang, Wei Liu, Yuanming Qi. Antioxidant and free radical scavenging activity of the extracellular death factor in Escherichia coli. Peptides, 2010, 31(10):1821-1825.

　　[13] Dong-dong Wu, Yan-feng Gao, Li-xiang Chen*, Yuan-ming Qi*, Qiao-zhen Kang, Hai-li Wang, Lin-yu Zhu, Yong Ye, Ming-xia Zhai. Anti-tumor effects of a novel chimeric peptide on S180 and H22 xenografts bearing nude mice. Peptides. 2010, 31(5):850-864.

　　[14] Yan-feng Gao, Zhan-qiang Sun, Feng Qi, Yuan-ming Qi*, Ming-xia Zhai, Hui-ping Lou, Li-xiang Chen, Yong-xin Li, Xian-yuan Wang. Identification of a new broad-spectrum CD8 T cell epitope from over-expressed antigen COX-2 in esophageal carcinoma. Cancer Letters, 2009, 284(1):55-61.

　　[15] Hui-ping Lou, Yan-feng Gao*, Ming-xia Zhai, Yuan-ming Qi*, Li-xiang Chen, Hong Lv, Ji-bing Yu, Yong-xin Li. A novel peptide from α5 helix of Asterina pectinifera cyclin B conjugated to HIV-Tat with cytotoxic and apoptotic effects against human cancer cells. Bioorganic & Medicinal Chemistry Letters, 2008, 18(16):4633-4637.

　　[16] Yan-feng Gao, Ming-xia Zhai, Wei-xia Liu, Xin Liu, Ye Yuan, Yuan-ming Qi*, Rui Wang*. Structure-activity relationships of the dimeric analogues of endomorphin-2 with different lengths of spacers. Protein & Peptide Letters, 2008, 15(3):275-279.

　　[17] Chang-Feng Hu, Chuan-Jun Zhu, Yan-Feng Gao, Xuan Shao, Rui Wang, Yu-Xin Cui. Characteristic Fragmentation Behavior of the Analogs of endomorphin-2 with Phenylglycine in Position 3 or 4 by ESI-FT Tandem Mass Spectrometry. Chinese Chemical Letters. 2008, 19(12):1479-1482.

　　[18] Yun Feng, Ying-wei Lu, Xin Lin, Yan-feng Gao, Qian-yu Zhao, Wei Li, Rui Wang*. Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse. Life Sciences, 2008, 82(13-14):752-763.

　　[19] Xuan Shao, Yan-feng Gao, Chuan-jun Zhu, Xue-hui Liu, Jin-long Yao, Yu-xin Cui, Rui Wang*. Conformational analysis of endomorphin-2 analogs with phenylalanine mimics by NMR and molecular modeling. Bioorganic & Medicinal Chemistry, 2007, 15(10): 3539-3547.

　　[20] Li-xiang Chen, Yuan-ming Qi*, Rui Wang*, Xin Duan, Yan-feng Gao, Ding-jian Yang. Roles of nitric oxide synthase inhibitor on antinociceptive effects of μ-Opioid agonist in mice. Protein & Peptide Letters, 2006, 13(10): 993-997.

　　[21] Yan-feng Gao, Xin Liu, Wei-xia Liu, Yuan-ming Qi, Xue-feng Liu, Rui Wang*. Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3 or 4. Bioorganic & Medicinal Chemistry Letters, 2006, 16(14):3688-3692.

　　[22] Yan-feng Gao, Xin Liu, Jie Wei, Bei-bei Zhu, Qiang Chen, Rui Wang*. Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2. Bioorganic & Medicinal Chemistry Letters, 2005, 15(7):1847-1850.

　　[23] Jie Wei, Xuan Shao, Mao-zhen Gong, Bei-bei Zhu, Yu-xin Cui, Yan-feng Gao, Rui Wang*. Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by α-aminoxy acids. Bioorganic & Medicinal Chemistry Letters, 2005, 15(12):2986-2989.

　　[24] Yi-feng Zhou, Rui Wang*, Zhao-qing Xu, Wen-jin Yan, Lei Liu, Yan-feng Gao, Chao-shan Da. Boc-L-proline as a new chiral ligand for enantioselective phenylacetylene addition to aromatic aldehydes. Tetrahedron: Asymmetry. 2004, 15(4):589-591.

　　[25] Xin Lin, Ding-jian Yang, Wen-qing Cai, Qian-yu Zhao, Yan-feng Gao, Qiang Chen, Rui Wang*. Endomorphins, endogenous opioid peptides, provide antioxidant defense in the brain against free radical-induced damage. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2003, 1639(3):195-202.

获得专利

　　[1] PLAC1抗肿瘤CTL表位肽及其应用. 专利授权号:ZL 201010205684.0

　　[2] PIWIL2抗肿瘤CTL表位肽及其应用. 专利授权号:ZL201010276917.6

　　[3] 抗结核CTL表位肽. 专利授权号:ZL 200910065403.3.

　　[4] MAGE-4抗肿瘤CTL表位肽及其应用. 专利授权号:ZL201010212512.5

　　[5] 结核分枝杆菌抗原限制性表位肽. 专利授权号:201010030225.3.

　　[6] 结核耐药相关外排蛋白来源抗结核CTL表位肽及其应用. 专利授权号:201110138646.2

　　[7] MTA1来源的抗肿瘤CTL表位肽及其应用. 专利授权号:201110138635.4

　　[8] PL2L60来源的CTL表位肽及其应用. 专利授权号:201210001557.8

编写教材

　　[1]生物化学实验原理与技术(普通高等教育"十二五"规划教材)，化学工业出版社，2010，副主编

　　[2]动物生物学与生理学实验指导，郑州大学出版社，2008年，副主编

荣誉

　　[1来自]第十一届中国国际多肽会"Yong Peptide Scientist Award"

　　各维讲热次听试没[2]"沈琼食管癌研究奖励右基金"优秀科研成果二等奖

　　[3]河南省优秀中青年骨干教师

　　[4]河南省教学技能竞赛二等奖

　　[5]河南省自然科学优秀论文一等奖2项

　　[6住济战效]河南省自然科学优秀论文什黄决比击防二等奖4项

　　[7]郑州大露位处各触增帮学校级青年骨干教师

　　[8]连年被评为"学生最满意教师"

　　[9]200360百科9年郑州大学生物工程系青年参联丰旧始就教师讲课比赛三等奖

　　[10]2010和2011年度河南省优秀硕影临京士学位论文，指导教师

　　[11到回旧美秋占提货须安]2007和2010年度郑州大学"挑战杯"活动特等奖，指导教师

　　[12]2009年郑州大学校级优秀本科生毕业论文1人，指导教师