李纪文

人名，学者，女。华东师范大学生命科学学院生命医学研究所副教授，硕士导师。高级研究助理。研究方向为雄性激素受体基因表来自达调控与前列腺癌和 蛋白SUMO修饰。曾参与一项973课题，"染色质解码的基础与临床研究"。发表论文1360百科4篇。

• 中文名称 李纪文
• 国籍 中国
• 民族 汉族
• 职业 副教授，硕士导师
• 毕业院校 复旦大学

简介

　　李纪文，华东师范大学生命科学学院生命医学研究所生物化学与分子生物学学科组副教授级高级研究助理。硕士导师。

简历

学习经历

　　1986-1990: 学士学位，生物化学专业，复旦大学

　　1995-1997: 硕士学位，生物化学专业，Hood Co来自llege, Frederick, Maryland, 360百科USA，

工作经历

　　1990-1994:研究助理，中国科学院上海川兰设门川意世争时有机生化所生物化学系。

　　1997-2003:研究技术员，Department of Cell Biology, Baylor College of Medici直景样ne, USA.

　　2003-2007:高级急燃系宁温总灯架明声光研究助理，Department of Cell Biology, Baylor College of Medicine, USA.

　　2007-至今:副教授，华东师范大学生命科学学院生命医学研究所

研究方向

　　1) 雄性激素受体基因表达调控与前列腺癌

　　2) 蛋员资林白SUMO修饰

科研速项目

　　1、2008年至今参与一项973课题，"染色质解码的基来自础与临床研究"。

　　2、360百科参与上海市科委细胞信号传导平台建设研究。

代表性的论文

　　查操由装游由换1.Chen, H.-B., Li, J., and Yang, J. 1992. Expression of a chemically synthesized gene for the mature rbcS from tobacco in E. coli.. In"Research in Photosynthesis" (Murata, n., ed), vol. III, 645-648.

　　2.Stolow, M.A; Bauzon, D.D;Li, J; Sedgwick, T; Liang, V.C-T; Sang, Q.行始载适便介粉东造A; and Shi, Y-B. (1996). Identificatio值几析今等厚法旧矛副卫n and character控牛看ization of a novel collagenase in Xenopus laevis: possible roles during frog development. Molecular Biology of the Cell, Vol. 7, 1471-1483.

　　3.Li, J; Liang, V.C-T; Sedgwick, T; Wong, J; and Shi呼, Y-B. 1998设. Unique organization and i怎卫农水钱道被nvolvement of GA油结出方刘给GA factors i映n transcriptional regulat工费沿调超村律ion of the Xenopus stromelysin-3 gene. Nucleic Acids Res. 26(另菜济友排拿卫亮12): 3018-西雷哥已3025

　　4. Li他, J., O'Malley B.W and Wong J. 2000. p300 requires its HAT activity and S超八岁最永茶在红RC-1 interaction motif to facilitate TR activation i能喜洲列重n chromatin. 九陆尽船角换故做花Mol. Cell. Biol. 20: 2031-2042.

　　5. Li, J,. Wang, J; Wang, J; Nawaz, Z; Liu, J., Jun, Q., and Wong J. 2000. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 19(16): 4342-4350.

　　6. Huang, Z., Li, J. and Wong J. 2002. Androgen receptor possesses an intrinsic-hormone-independent trans-activation activity. Molecular Endocrinology. 16: 924-937.

　　7. Li, J; Lin, Q; Wade, P., Wang, W and Wong J. 2002. Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression. Genes & Development 16: 687-692.

　　8. Li, J., Lin, Q., Yoon, H-G., Huang, Z., Strahl, B.D., Allis, C.D., and Wong J. 2002. Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. Mol Cell Biol 22 (16): 5688-5697.

　　9.Yoon HG, Chan DW, Huang ZQ, Li, J, Fondell JD, Qin J and Wong J. 2003. Purification and Functional Characterization of the Human N-CoR Complex: the Roles of HDAC3 and two WD-40 Repeat Subunits TBL1 and TBLR1. EMBO J 22(6):1336-1346.

　　10. Lee KC#, Li, J#, Cole PA, Wong J* and Kraus L*. 2003. Transcriptional activation by thyroid hormone receptor involves chromatin remodeling, histone acetylation, and cooperative stimulation by p300 and SRC coactivators. Molecular Endocrinology, 17(5):908-22. (#equal contribution and co-corresponding authors.)

　　11.Huang ZQ, Li, J, Sachs LM, Cole PA and Wong J. 2003. A Role for Cofactor-Cofactor and Cofactor-Histone Interaction in Targeting of CBP/p300, SWI/SNF and Mediator for transcription. EMBO J 22(9):2146-2155.

　　12.Stewart MD, Li J and Wong J. 2005 Relationship between H3 lysine 9 methylation, transcription repression and heterochromatin protein 1 recruitment. Mol Cell Biol;25(7):2525-38.

　　13.Burd CJ, Petre CE, Morey LM, Wang Y, Revelo MP, Haiman CA, Lu S, Fenoglio-Preiser CM, Li J, Knudsen ES, Wong J and Knudsen KE. 2006 Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. Proc Natl Acad Sci U S A; 103:2190-5.

　　14.Li, J., Fu J, Toumazou C, Yoon HG, and Wong J. 2006. A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin. Mol Endocrinol 20:776-85.